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This led to the study of fentanyl-induced amnesia, which was documented in a 2018 report in the New England Journal of Medicine and observed in a group of Massachusetts patients. In some people, fentanyl kills neurons by causing cells in the hippocampus, an area of the brain already vulnerable to oxygen deprivation during an overdose, to grow out of control.
Because the syndrome is so rare, he encountered some doctors who were skeptical about the link between fentanyl and amnesia. The book follows how others, like Jed Barash, medical director of Soldier’s Home in Chelsea, Massachusetts, have stubbornly sought answers and ultimately confirmed how opioids can damage the hippocampus.
“These Alzheimer’s researchers and neuroscientists are heroes. We owe them a debt of gratitude because I think that eventually, if not cures, at least there will be cures,” he says.
Aguirre, who is currently working on a medical fiction book, credits MIT for her willingness to make these leaps. “Even being able to survive there gave me the confidence to believe that if you work hard enough, you’ll eventually work things out,” he says.
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