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Bone marrow transplant is not a realistic option for most patients. These types of transplants are highly invasive and risky, so they are usually only offered to people with cancer who have exhausted all other options.
There have been only two known cases of HIV treatment so far. Timothy Ray Brown, nicknamed the “Berlin Patient,” remained virus-free for 12 years until he died of cancer in 2020. Another patient in 2019, later defined Adam Castillejo was reportedly being treated for HIV, confirming that Mr. Brown’s case was not a coincidence.
Both men received bone marrow transplants from donors who carried a mutation that prevented HIV infection. The mutation has been identified in only about 20,000 donors, most of them of Northern European origin.
In previous cases, because bone marrow transplants altered their entire immune system, both men suffered punishing side effects, including graft versus host disease, a condition in which the donor’s cells attack the recipient’s body. Mr. Brown nearly died after his transplant. Mr Castillejo’s treatment was less intense, but over the years after transplantAccording to her doctors, she lost nearly 70 pounds, developed hearing loss, and recovered from multiple infections.
In contrast, the patient’s physician at Weill Cornell Medicine, Dr. JingMei Hsu said that the woman in the last case left the hospital on the 17th day after her transplant and did not develop graft versus host disease. Dr. The combination of cord blood and his relative’s cells may have protected him from many of the brutal side effects of a typical bone marrow transplant, Hsu said.
Elected president of the International AIDS Society, who was not involved in the study, Dr. “Previously, it was thought that vaccine versus host disease could be an important reason for HIV treatment in previous cases,” said Sharon Lewin. Dr. The new results dispel that notion, Lewin said.
Woman now past middle age (refused to reveal full age due to privacy concerns) Diagnosed with HIV in June 2013. Antiretroviral drugs kept virus levels low. He was diagnosed with acute myeloid leukemia in March 2017.
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