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The Centers for Disease Control and Prevention recommended on Thursday that Covid vaccines other than Johnson & Johnson should be preferred after its advisors cited growing evidence that the company’s vaccines could now trigger a rare blood clotting disorder that has been linked to dozens of cases and at least nine deaths. in the United States last year.

The decision accepted the advice of an expert panel that effectively discouraged vaccine providers and adults from using Johnson & Johnson’s injection. New data showed a higher risk than previously known for the condition of blood clots. The risk was highest among women aged 30 to 49, estimated at 1 in 100,000 who received the company’s vaccine.

Johnson & Johnson’s vaccine is not being removed from the market. The agency said it will remain an option for people “unnecessary or unwilling” to take the more popular shots from Moderna or Pfizer-BioNTech.

The recommendation is the latest pushback for a vaccine that has largely fallen out of favor in the United States. The company’s vaccine did not live up to its early promise as a traditional, single, finished format that was easy to administer in more isolated or rural communities or among people who were timid about taking two doses.

about 16 million people In the United States, 73 million fully immunized with Moderna’s vaccine and 114 million with Pfizer-BioNTech vaccines received the Johnson & Johnson vaccine as primary immunization. Only 1.6 percent of Americans who received a booster chose Johnson & Johnson.

Food and Drug Administration this week updated guide published He spoke about the risks of blood clotting disorders associated with Johnson & Johnson’s vaccine, but reiterated that the benefits outweigh the risks.

Dozens of countries have authorized the Johnson & Johnson vaccine and are using it as part of their vaccination campaigns. But while it remains in high demand in some parts of the world, it has lost popularity in many countries due to safety concerns and its relatively low effectiveness against Covid.

Some governments have taken action to place restrictions on Johnson & Johnson’s shot because of the risk of blood clots. Finland, Denmark and Slovenia stopped using it, and many other countries rank it lower for use than Pfizer-BioNTech and Moderna’s vaccines. Some countries have also recommended that doctors counsel women under 50 about potential risk.

The CDC panel’s recommendation comes amid an increase in virus cases, driven by the Delta coronavirus variant and Omicron, the latest version that has already become dominant in some countries and is spreading rapidly in the UK and United States.

Several laboratory experiments show that a single dose of Johnson & Johnson injections can provide little defense against Omicron infection. Company said last month He said he tested blood samples from clinical trial participants who received the vaccine as a booster to see how the vaccine-induced antibodies acted against Omicron.

At Thursday’s meeting of the Vaccine Practices Advisory Committee, CDC officials into detail About the coagulation-related syndrome identified in 54 people vaccinated before the end of August in the United States. Overall, the rate of the condition was 3.8 cases per million people given the vaccine.

People who received a Johnson & Johnson vaccine months ago are not considered to be at risk for the clotting condition, as the onset of symptoms in diagnosed cases typically occurred approximately nine days after vaccination.

An increased risk for the condition has also been associated with the shot from AstraZeneca, which is not authorized in the United States. Not affiliated with Moderna or Pfizer vaccines.

Evidence is increasingly showing that one dose of Johnson & Johnson vaccine provides far less protection against infection than other vaccines. federal health officials authorized in October boosters for people who received a single shot of the company’s vaccine at least two months ago. By allowing a “mix and match” approach, they allowed people to get a second shot, but not a Pfizer or Moderna vaccine.